Histone H2AX
نویسندگان
چکیده
منابع مشابه
Histone H2AX in DNA repair
In eucaryotic cells, DNA is bound to various proteins and forms a complex nucleoprotein structure called chromatin. Indispensable and ubiquitous chromatin components are histones, small proteins of highly conserved primary structure. Two molecules of each H2A, H2B, H3 and H4 type, form the nucleosomal core around which a 146 base pair (bp) stretch of DNA is wrapped. Histone H1 is bound to about...
متن کاملH2AX: the histone guardian of the genome.
At close hand to one's genomic material are the histones that make up the nucleosome. Standing guard, one variant stays hidden doubling as one of the core histones. But, thanks to its prime positioning, a variation in the tail of H2AX enables rapid modification of the histone code in response to DNA damage. A role for H2AX phosphorylation has been demonstrated in DNA repair, cell cycle checkpoi...
متن کاملCritical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair
The presence of phosphorylated histone H2AX (γ-H2AX) is associated with the local activation of DNA-damage repair pathways. Although γ-H2AX deregulation in cancer has previously been reported, the molecular mechanism involved and its relationship with other histone modifications remain largely unknown. Here we find that the histone methyltransferase SUV39H2 methylates histone H2AX on lysine 134...
متن کاملEvaluation of chemical phototoxicity, focusing on phosphorylated histone H2AX
Histone H2AX is a minor component of nuclear histone H2A. The phosphorylation of histone H2AX at Ser 139, termed γ-H2AX, was originally identified as an early event after the direct formation of DNA double-strand breaks (DSBs) by ionizing radiation. Now, the generation of γ-H2AX is also considered to occur in association with secondarily formed DSBs by cellular processing such as DNA replicatio...
متن کاملH2AX: tailoring histone H2A for chromatin-dependent genomic integrity.
During the last decade, chromatin research has been focusing on the role of histone variability as a modulator of chromatin structure and function. Histone variability can be the result of either post-translational modifications or intrinsic variation at the primary structure level: histone variants. In this review, we center our attention on one of the most extensively characterized of such hi...
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ژورنال
عنوان ژورنال: Cell
سال: 2003
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(03)00566-x